A review on computer-aided chemogenomics and drug repositioning for rational COVID-19 drug discoveryArticle Published on 2022-11-012022-11-15 Journal: Chemical biology & drug design [Category] 변종, 신약개발, 치료기술, 치료제, [키워드] analyzed application assist chemogenomics compounds Computational drug computational drug discovery Computational methods coronavirus coronavirus disease CoV COVID-19 CoVs drug candidate Drug discovery drug repositioning drugs Efficiency epidemic diseases example feasible Host in silico approaches molecular docking other variants outcome Polypharmacology polypharmacology. Protein provide reflected reported Spread therapeutic target time-consuming Toxicity turn unique virus virus [DOI] 10.1111/cbdd.14136 PMC 바로가기
Two Ligand-Binding Sites on SARS-CoV-2 Non-Structural Protein 1 Revealed by Fragment-Based X-ray ScreeningArticle Published on 2022-10-182022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] affinity Antiviral antiviral drug applicability assays atomic resolution caused consequence Consequences conserved coronavirus CoV COVID-19 cross-binding effects Degradation drug design effective Efficiency expression fragment-based X-ray screening functional Health Host host mRNA IFN infection rate inhibitor interferon ligands limitation MERS coronaviruses mortality rate N-terminal domain non-structural protein non-structural protein 1 outbreak pandemic Pathways Protein provide Replication respiratory Revealed Safe SARS-CoV-2 Screening Site starting point structure-based drug design. unique vaccination Vaccines variety virulence virus X-ray X-ray crystallography [DOI] 10.3390/ijms232012448 PMC 바로가기
AuNP-based biosensors for the diagnosis of pathogenic human coronaviruses: COVID-19 pandemic developmentsArticle Published on 2022-10-012022-11-15 Journal: Analytical and bioanalytical chemistry [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy Antigen Asymptomatic carrier AuNP AuNPs biofluid Biomarker CoV COVID-19 epidemic COVID-19 pandemic CoVs CRISPR Diagnosis Diagnostic method Early detection example gold helping higher risk highlight highly pathogenic CoV Human human coronavirus human coronaviruses identify Laboratory MERS-CoV nanobiosensors nucleic acids optical outbreak pathogenic Pathogenic. platform point-of-care Probability Protein provided RT-PCR SARS-CoV-1 SARS-CoV-2 Spread the disease the SARS-CoV-2 Transmission treatment intervention virus viruses [DOI] 10.1007/s00216-022-04193-2 PMC 바로가기
Upregulation of hsa_circ_0004812 promotes COVID-19 cytokine storm via hsa-miR-1287-5p/IL6R, RIG-I axisArticle Published on 2022-10-012022-11-16 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Asymptomatic bioinformatics Bioinformatics analysis cDNA synthesis competing contagious correlation Correlation analysis CoV COVID-19 COVID-19 cytokine storm cytokine Cytokine storm expressed expression expression level expressions healthy controls hsa_circ_0004812 hsa-miR-1287-5p IL-6R IL6R in silico In-vitro Interaction material molecular mechanisms mononuclear cell negative control outcome pandemic Patient patients patients with asymptomatic PBMC Peripheral blood positive correlation positively correlated predicted promote qRT-PCR relative expression RIG-I RNA SARS-CoV-2 sponging effect. Symptom symptomatic the Coronaviridae the SARS-CoV-2 total RNA virus was performed [DOI] 10.1002/jcla.24666 PMC 바로가기
Humoral cross-coronavirus responses against the S2 region in children with Kawasaki diseaseArticle Published on 2022-10-012022-11-15 Journal: Virology [Category] COVID19(2023년), SARS, 진단, [키워드] antibodies antibody approach children Control Coronary Coronary aneurysms coronavirus correlated CoV CoVs Cross-immunity cross-reactive cross-reactivity effort explain feature febrile humoral Immunity Infection Inflammatory Kawasaki disease MIS-C multisystem inflammatory syndrome in children OC43 pathology Protein raise reactivity recent Region responses against Safe SARS CoV-2 SARS-CoV-2 SARS-CoV-2 S2 SARS-CoV-2. shown Support syndrome the Spike Vaccine vascular inflammation [DOI] 10.1016/j.virol.2022.08.010 PMC 바로가기
Discovery of the Cryptic Sites of SARS-CoV-2 Papain-like Protease and Analysis of Its DruggabilityArticle Published on 2022-09-242022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료기술, 치료제, [키워드] activated active sites binding pocket binding site caused changes in conformational change CoV COVID-19 COVID-19 pandemic cryptic pocket cysteine protease develop drug druggability druggability. drugs help induce inhibitor inhibitors MixMD New coronavirus outbreak pandemic Pathogenesis patients physicochemical property PLPro predict probe Probeview promote Protein Research residue Respiratory disease resulting SARS-CoV-2 SARS-CoV-2 PLpro Schrodinger Site solvent target protein TRAPP treat virus was used [DOI] 10.3390/ijms231911265 PMC 바로가기
A Study on the Nature of SARS-CoV-2 Using the Shell Disorder Models: Reproducibility, Evolution, Spread, and AttenuationArticle Published on 2022-09-232022-11-16 Journal: Biomolecules [Category] SARS, 변종, [키워드] applied attenuation bat-CoV contagiousness coronavirus Coronaviruses correlated CoV COVID COVID-19 demonstrated disorder enzyme greater Hard immune system implication intrinsic Long COVID lung membrane protein Nature nucleocapsid protein nucleoprotein observation omicron pangolin Particle PID predicted PROTECT Replication Saliva SARS-CoV-2 shell supported tissues transmissions variant Viral load virion virulence virulence. virus [DOI] 10.3390/biom12101353 PMC 바로가기
A comprehensive review of BBV152 vaccine development, effectiveness, safety, challenges, and prospectsArticle Published on 2022-09-132022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] Administered Adults age antigenic approved booster children clinical development comparable country CoV COVID-19 pandemic COVID-19 severity disease Effectiveness Efficacy Emergency use Emergency use authorization generate geometric mean titer group Healthcare system Heterologous heterologous prime and boost vaccines heterologous prime-boost immune response inactivated Inactivated vaccine inactivated virus adjuvanted vaccine increase in India induce Like memory B morbidity Mortality neutralization neutralization titer original antigenic sin over pandemic pediatric phase Population prime and boost reactogenicity reduce reduction in robust safety profile SARS – CoV – 2 SARS-CoV-2 variant seroconversion rate symptomatic COVID-19 disease synergy T-cell responses TLR7/8 vaccinated individuals vaccination Vaccine vaccine challenges Vaccine development vaccine dose Vaccines variants of concern variants of concern (VOCs). virus VOCs waning immunity [DOI] 10.3389/fimmu.2022.940715 PMC 바로가기
Deciphering SARS CoV-2-associated pathways from RNA sequencing data of COVID-19-infected A549 cells and potential therapeutics using in silico methodsArticle Published on 2022-09-022022-11-16 Journal: Medicine [Category] SARS, 유전자 메커니즘, [키워드] A549 cell activated Activation acute respiratory syndrome addition Analysis Atypical candidate caused characterized CLC complications CoV COVID COVID-19 COVID-19 infection cytokine deaths DEGs Determining differentially expressed gene disease drug effective experimental validation Gene Expression Omnibus gene signatures Genomics GEO GSE147507 human-to-human transmission identify IFNβ IL-17 IL-1β Illumina in silico In silico method influenza A Interaction interferon beta interferon regulatory factor IRF3 IRF9 JQ1 knowledge mechanism Methylprednisolone mock-treated pathology pathway Pneumonia Prednisolone Quality control receptors RNA RNA sequencing RNA sequencing data SARS CoV-2 signaling pathway signaling pathways small molecule STAT2 the Coronaviridae the disease therapy Transcription Treatment underlying disease upstream Viral protein virus infection was used with COVID-19 Wuhan, China [DOI] 10.1097/MD.0000000000029554 PMC 바로가기
Is IFN expression by NK cells a hallmark of severe COVID-19?Research article Published on 2022-09-012022-10-05 Journal: Cytokine [Category] 변종, 치료기술, 치료제, [키워드] addition CD107a clinical form contribute CoV COVID-19 cytolytic cytotoxic activity Cytotoxic granules decrease Defense disease elicited Express expression form Frequency Granule granzyme B groups hallmark Host IFN IFN-α IFN-γ immune responses immune system individual Innate immunity interferons involved Ki-67 Killer cell mechanism Mild natural Natural killers NK cell NK cells pathogenesis of COVID-19 PBMC PBMCs peptide pool profile question recovered COVID-19 patient reduced SARS-CoV-2 severe COVID-19 severity significant increase spike the disease the healthy viruses Volunteer [DOI] 10.1016/j.cyto.2022.155971 [Article Type] Research article